Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety

Mental health and active aging are two of the main concerns in 21st century. To search for new neuroprotective compounds, extracts Codium tomentosum Stackhouse Fucus vesiculosus L. were obtained through multi-step (four step) subcritical water extraction using a temperature gradient. The safety assessment was performed by screening pharmaceutical compounds pesticides UHPLC-MS/MS, iodine arsenic levels ICP-MS. Although free pesticides, presence high contents found first steps. Thus, health-benefits only evaluated fractions steps 3 4 from process. These tested against five brain enzymes implicated Alzheimer’s, Parkinson’s, major depression etiology as well reactive oxygen nitrogen species, having been observed strong enzyme inhibition radical scavenging activities step both seaweed species. Regarding variation chemical composition during extraction, 1 richest phenolic compounds. With increase temperature, Maillard reaction, caramelization thermo-oxidation occurred, resulting products positively affected antioxidant capacity effects.